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Atopic Dermatitis
What is Atopic Dermatitis
Between 5% and 20% of children worldwide are affected by AD. Sixty percent of affected children continue to have persistent AD after puberty, and nearly 80% of patients are at risk for developing respiratory allergies, including allergic rhinitis and asthma.
The concordance rate for monozygotic twins with Atopic Dermatitis is 77% as compared with 15% for dizygotic twins with AD, indicating a genetic role in the pathogenesis of AD. However, the mode of inheritance for Atopic Dermatitis is not known. Various candidate genes for asthma and allergic diseases, including the region on chromosome 5q31 that contains the cytokine genes that regulate serum IgE levels and eosinophilia, have been studied for possible association with AD. It is likely that the expression of Atopic Dermatitis, as with other atopic diseases, involves the interaction of multiple genes, the environment, and the immune system.
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