Erythema Multiforme

What is Erythema Multiforme

Erythema multiforme (EM) represent a spectrum of immunologically mediated diseases due to hypersensitivity to drugs or infections. There is no uniformly accepted definition or classification of Erythema multiforme, and understanding of it exact immunologic basis is lacking. Erythema multiforme, or the classic von Hebra type of erythema multiforme, is a symmetric eruption with a predilection for the extremities. The characteristic primary lesion is a "target" comprised of three zones. Centrally there is a disk surrounded by an elevated, pale ring. This is concentrically bordered by a zone of erythema. Mucosal involvement occurs in a majority of cases of EM; however, it is usually limited to the oral mucosa and typically is not severe.

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