Sarcoidosis Symptom


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Home :: Sarcoidosis Symptom

Sarcoidosis Symptom - What are the sign and Symptoms of Sarcoidosis

What are the Symptom of Sarcoidosis

The severity of manifestations in sarcoidosis can vary from an asymptomatic chest roentgenogram to death in approximately 4% of patients. The most common symptom and signs of sarcoidosis are

  • fatigue (27%),
  • malaise (15%),
  • cough (30%),
  • shortness of breath (28%), and
  • chest pain (15%).

Ninety-two percent of patients of Sarcoidosishave abnormal chest roentgenograms as symptom. Pulmonary parenchymal involvement is more ominous than the more frequent hilar adenopathy. Restrictive lung disease and cor pulmonale can develop. Granulomatous uveitis is the most frequent visual problem. Skin lesions occur in 30% of cases. They may be nondescript, but commonly are papular or nodular, erythematous, or violaceous lesions, which exhibit typical granulomas on histologic examination. Erythema nodosum is common in sarcoidosis of acute onset. Liver involvement is almost always asymptomatic and is evidenced mainly by hepatomegaly. An elevated alkaline phosphatase level may suggest the presence of liver granulomas.

Vasculitis with vascular granulomas or nonspecific histology has been seen in sarcoidosis and occasionally can be life threatening Patients with vasculitis are often thought to have other rheumatic diseases. Parotid involvement and sicca features can also mimic Sjögren syndrome.


1. Muscle: Sarcoid granulomas in muscle are often asymptomatic, but they may be accompanied by the symptoms like local pain and tenderness, cramps, pseudohypertrophy, palpable nodules, and, occasionally, associated fasciitis. A symmetric proximal myopathy with weakness has also been described and reported to occur without evident sarcoidosis in other tissues.

2. Bone: Phalangeal cysts, often considered a helpful diagnostic clue in sarcoidosis, were described in 14% of patients in one series.

3. Arthritis: Arthritis was first described with sarcoidosis in 1936. Since then, arthritis, periarthritis, or arthralgia has been reported in 2% to 38% of patients in various series. Chronic sarcoidosis is associated with fewer joint complaints than the acute form.

Other Symptom of sarcoidosis

Acute sarcoidosis (Lofgren's syndrome)

  • Often periarticular and tender, erythematous, warm Swelling
  •   Ankles and knees almost invariably involved
  •   Joint involvement possibly the initial manifestation (chest film normal)
  •   Joint motion possibly normal and pain absent or minimal
  •   Synovial effusions infrequent and generally only mildly


  •   Usually nonspecific mild synovitis on synovial biopsy
  •   Self-limited, lasting weeks to months

Chronic sarcoidosis

  •   Arthritis possibly acute and evanescent, recurrent, or Chronic
  •   Noncaseating granulomas often demonstrable in synovium
      Usually nondestructive, despite chronic or recurrent Disease

More related Topics:

Sarcoidosis Treatment
Sarcoidosis Symptom
Sarcoidosis Disease

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